Is Pyrrole Disorder Causing you to Suffer

by Greg Newson October 20, 2017 0 Comments

What is Pyrrole Disorder?

What Is Pyrrole Disorder?

Pyrrole Disorder, commonly known as Pyroluria is a condition in which  sufferers are unable to effectively utilise or uptake Zinc, Vitamin B6 1-7 and Biotin8.

Waste products are produced by all cells and the waste produced by the haem molecules is hydroxyhemopyrrolin-2-one (HPL) also known as Pyrrole. It is HPL that binds to and increases the urinary excretion of Zinc, Vitamin B6 and Biotin. People who suffer from Pyrrole Disorder produce excessive amounts of HPL resulting in these nutritional deficiencies. Pyrrole Disorder sufferers also have lower levels of the Omega 6 Fat, GLA, which is due to the requirements of Zinc and Vitamin B6 in converting alpha-Linolenic acid to GLA.

Supplementation helps to to reduce HPL levels and the severity of the conditions, signs and symptoms that Pyrrole Disorder sufferers experience.

 



Conditions associated with Pyrrole Disorder

Due to the various bodily functions of Zinc, Vitamin B6 and Biotin the symptoms of Pyrrole Disorder can be quite broad and far reaching. Below is a list of some common health conditions associated with Pyrrole Disorder and the percentage of those sufferers with elevated HPL levels.

Acute Intermittent Porphyria 100% Down Syndrome 71%
ADD/ADHD 47% Epilepsy 44%
Alcoholism 20-84% Learning Difficulties 40-47%
Asperger’s Syndrome 46-48% Latent Acute Intermittent Porphyria 70%
Autism 46-48% Manic Depression 47-50%
Bi-Polar Disorder 46% Neurosis/Neurotic 20%
Criminal Behaviour 71% Schizophrenia 59-80%
Depression 46%

Violent / Criminal Offenders

33-71%

For a full list of conditions associated with Pyrrole Disorder please click here.

Signs and symptoms of Pyrrole Disorder

As previously mentioned the roles of Zinc, Vitamin B6 and Biotin are vast and as such there are many potential side effects associated with their deficiency. Below is a short list of some of the more common signs and symptoms associated with Pyrrole Disorder. 

Anger – explosive Intolerance to alcohol and drugs
Anxiety/anxious Lack of regular menstrual cycles
Argumentative Low libido
Delayed puberty Morning nausea
Delusions Poor morning appetite
Depression Prone to stitches
Dyslexia Reading difficulties
Fatigue Sensitivity to bright light, noise and smells
Emotionally unstable Social withdrawal
Frequent infections Substance abuse
Hyperactivity Temper tantrums

For a full list of signs and symptoms associated with Pyrrole Disorder please click here.

Read our blog on the 9 most Common Pyrrole Disorder Symptoms

Unusual Body Appearances Associated with Pyrrole Disorder

For some Pyrrole Disorder sufferers they can also have multiple abnormalities in their physical appearance. Some of the more common physical appearances associated with Pyrrole Disorder are listed below.

Acne Overcrowding of teeth
Early greying of hair Poor wound healing
Hypo-pigmentation of skin Skin appears paper thin
Inability of skin to tan Stretch marks
Lack of hair on eyebrows or eyelashes White spots on fingernails

For a full list of body signs associated with Pyrrole Disorder please click here.

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What causes Pyrrole Disorder?

Evidence suggests that for some sufferers, Pyrrole Disorder is a genetic condition. Research and statistics indicate that if a parent, grandparent, uncle, aunt, sister or brother suffers from Alcoholism, Bi-Polar Disorder, Schizophrenia, Major Depression or has committed Suicide, that there is a greater risk of Pyrrole Disorder in other family members.

Studies indicate that Lifestyle Factors can also play a role in driving up HPL levels, thus leading to Pyrrole Disorder. 

  • Poor dietary choices and poor digestive health can lead to an increase in HPL levels (9) 
  • Studies have shown that zinc deficiency increases bowel permeability leading to a condition know as Leaky Gut Syndrome (10-20). Leaky Gut Syndrome increases HPL in susceptible Pyrrole Disorder sufferers.
  • It is a well known fact that stress damages the intestinal wall and causes intestinal inflammation. Both of which lead to an increase in Leaky Gut Syndrome  (9, 21-23).
  • Research discovered that stress increases the production of HPL (2,6,43)
  • An unpublished US navy study conducted in 1992 found a very rapid increase in HPL levels in male volunteers who were subjected to the stress of a brief cold-water immersion (44)
  • Dysbiosis, an overgrowth of detrimental bacteria in the intestinal tract, has also been linked to an increase in blood HPL levels. Dysbiosis is a major cause of Leaky Gut Syndrome (17, 24)
  • Stress increases the adherence of bad bacteria to the intestinal wall within 30 minutes (25).
  • Alcohol, smoking, drugs and heavy metal exposure dramatically increase blood HPL levels. This is why sufferers of Pyrrole Disorder tend to get a worsening of their symptoms 24 to 48 hours after recreational drug use or a big night on the town drinking.
  • For more information on What Causes Pyrrole Disorder

What Damage Can HPL Do?

  • Pyrroles (HPL) are classed as 'nerve poisons' (26) and can damage nerves, nerve cells.
  • HPL decreases haem levels. Animal studies have shown that HPL caused a decrease in liver haem, and it's haem detoxifying enzyme cytochrome P450, by up to 55% over a 48 hour period (30)
  • Nerves metabolic activity is highly dependent on haem,  low levels of haem lead to a metabolic crisis resulting in neuronal (nerve) cell death (27-29).
  • Vitamin B6, Biotin and Zinc are all required for the production of haem and a reduction in these nutrients results in sub normal haem levels (28,31).  
  • Haem levels are further depressed by stress and heavy metal exposure (28).  
  • Low levels of haem results in an excess production of the toxic free radical nitric oxide, which can cause serious damage to brain tissue and is suspected to play a role in schizophrenia, autism and Down Syndrome (38-42).
  • Antioxidants protect cells from free radical damage. The body has 3 major antioxidant defence enzymes; Glutathione, Catalase and Superoxide Dismutase. All of these enzymes require  Zinc or Vitamin B6 in some part in their production.
  • A marginal deficiency of vitamin B6 is associated with lower levels of Glutathione production and cell mitochondrial (cell battery) decay (32-34)
  • Catalase consists of four protein subunits, each requiring hame. Autism and Schizophrenia sufferers have lower levels of catalase (35-37).

Is Pyrrole Disorder a Real Condition?

Unfortunately with many health conditions that are untreatable by conventional medicine they are deemed not real or don't exist. Regrettably, Pyrrole Disorder falls into this bracket, mainly because there are no drugs to increase levels of Vitamin B6, Biotin or Zinc and that most doctors are not trained in nutrition. Coupled with this there is misleading information available on the web, which is written by unqualified people who don't know or understand Pyrrole Disorder. Sadly, this combination leads people to believe that Pyrrole Disorder is a myth, and as such allows them no effective treatment or a proper diagnosis of Pyrrole Disorder.

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Is Pyrrole Disorder Causing you to Suffer References Please click here.

The information provided here is of a general nature intended for educational purposes only. We make no claims to diagnose, treat, prevent, alleviate or cure illnesses or diseases with any information or product stated. With any health issue we suggest you consult your healthcare professional before undertaking any health treatment.

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Greg Newson
Greg Newson

Author

Greg Newson is a qualified Naturopath, Herbalist, Nutritionist and Health Enthusiast who is passionate about wellness and dedicated in educating people of the enormous potential of natural medicine.