Many people when researching Pyroluria are overcome by the amount of potential symptoms associated with the disease. To make it easier we have listed the 9 most common Pyroluria symptoms we come across in clinic and a link to a complete list of symptoms at the bottom of the page. Before we go ahead and name our top 9, it’s important to understand why there are so many symptoms associated with Pyroluria.
When coming across the multitude of potential Pyroluria symptoms many people fail to realise the biochemical roles that Zinc, Vitamin B6 and Biotin have within the body. Their roles are so vast that I’m surprised there are not more potential symptoms.
Zinc is paramount for proper function of the immune, nervous and sexual systems and is involved in over 300 chemical reactions within the body.
Vitamin B6 is essential for the nervous, cardiovascular and immune systems as well as being a catalyst in over 100 enzyme reactions.
Biotin is of extreme importance for the nervous and digestive systems, it is necessary for the manufacture of fatty acids, the breakdown and utilisation of amino acids and the production of glucose from non-carbohydrate foods.
Depression is commonly associated with Pyroluria because to produce serotonin, the body’s happy, feel-good brain chemical, zinc and vitamin B6 are vital. These nutrients help to convert the amino acid tryptophan into serotonin. Low levels of zinc and vitamin B6 cause the inefficient operation of the serotonin biochemical pathway, resulting in depression.
Anxiety and panic attacks can be associate with a serotonin deficiency, but are more commonly caused by low GABA levels. GABA is the body’s major relaxing and tranquillising neurotransmitter. Zinc and Vitamin B6 are required to convert the body’s excitatory neurotransmitter Glutamate into GABA. If the process doesn’t occur effectively then a person becomes more prone to nervousness, anxiety, panic attacks, racing mind, insomnia and convulsions. GABA deficiency can be measured via the Mental Health Test, which also reports on other neurotransmitter imbalances including Serotonin, Dopamine, Adrenaline, Noradrenaline and Glutamate.
To initiate sleep melatonin is needed. However melatonin is manufactured from serotonin, which we know from Pyroluria Symptom number 1 requires zinc and Vitamin B6. While melatonin is required to maintain sleep, GABA is essential to prevent night time waking and the inability to fall back to sleep after waking.
Stretch marks are considered common in people that grow too quickly in one direction i.e. up or sideways. Unfortunately stretch marks are a symptom of zinc and vitamin C deficiency and can easily be prevented with proper nutrition and the correct Pyroluria Treatment.
White spots on the finger nails are a common sign that the body is severely deficient in zinc. This along with stretch marks are one of the two tell tail visual signs that Pyroluria may be an underlying cause.
Zinc is the commander and chief of the immune system. It is present in every white blood cell, in stomach acid, on every mucous membrane (internal body cavity) and the skin. It is our first line of defence agains bacteria or pathogenic infection. Low zinc equals a weakened immune defense system, which allows invading pathogens to take hold and infect the body.
This is a condition in which the normal colour of the skin become paler than the surrounding skin. Melanin is the substance that browns the skin, but it is very susceptible to hydrogen peroxide, a free radical. Hydrogen Peroxide is eliminated from the body via the antioxidant enzyme Catalase, which is dependant on zinc and vitamin B6 for manufacture. Catalase is often deficient in Pyroluria sufferers and it’s deficiency is also associated with early greying of the hair.
Testosterone is essential in both men and women to maintain sex drive and yes you guessed it, zinc is essential for the manufacture of testosterone. Oysters are the highest know source of zinc, hence them often being referred to as an aphrodisiac.
Biotin, Vitamin B6 and Zinc have a calming effect on the brain due to their varied roles in the production the neurotransmitters GABA, Serotonin and Dopamine along with supporting nervous system function. Studies have shown that mood swings, aggitation and mental health disorders are more prevalent in nutrient deficient individuals.
For a full list of the symptoms associated with Pyroluria please click here.
For other related articles on Pyroluria, please refer to the links below;
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